The benefits associated with taking antipsychotics for those with schizophrenia are thought to considerably outweigh drawbacks – including volumetric reductions. Mitchell L. Glaser, MD I do feel dumber after my last psychosis, cant work properly and get more tired. A toxic psychosis from poisoning or drug overdose could be a symptom of structural brain damage, but not because of psychosis, but the toxic condition. In the past, I would have just crossed the border, but now I am on public trust, and so the situation has become more tricky. Those studies have found very little evidence for major brain damage in people who use cannabis on a regular basis. Primarily a disorder of reduced excitation in an attenuated CNS, this explains why all the neuroleptics are convulsants It took awhile before researchers considered the fact that maybe the brain volume loss among those with schizophrenia may actually be a result of their antipsychotic treatment. Reductions in global brain volume means that nearly every aspect of brain functioning has potential to become impaired. Individuals with more volume loss had been on higher doses than those without as much loss. Suggested strategies include: taking the smallest effective dose, only taking antipsychotics if necessary, considering the specific antipsychotic (some may contribute to greater volume loss than others), and actively work to improve your brain health. The authors of the study suggest conducting careful risk-benefit analyses when prescribing these drugs; especially for “off-label” conditions. (Editorial).British Journal of Psychiatry, 198, 85-87. Whether they do or don’t. by itself i mean untreated psychosis, there have been no proof that psychosis itself , if untreated ,causes damage/ shrinkage /loss of the brain tissue but the use of Aps definitely caused the issue , i really dun know, what ‘s your opinion? You can also subscribe without commenting. You, as a reader of this website, are totally and completely responsible for your own health and healthcare. And, regardless of the cause-and-effect realities involved, immediate clinical attention for symptoms of psychosis is widely recommended. As an example, some individuals are prescribed Seroquel for insomnia. Despite the fact that symptoms need to be controlled, they can often be managed with a much lower dose than is suggested. Each individual diagnosed with schizophrenia was noted as having a total of between 2 and 5 scans to determine brain volume changes over the course of approximately 7 years. Whether or not having the minimum effective dose is important or not. lithium) that can be utilized over a long-term without any significant brain volume loss. If you or a loved one has suffered brain damage due to drug abuse, it’s impossible to say what is repairable and what is not purely based on symptoms or diagnosis. If a patient is in the placebo arm, then they are not receiving treatment for their psychotic symptoms. Permanent meth-induced psychosis is a worst-case scenario. I am about to delete my account because personal histories are not accepted on this site if you do not push meds. Exploring Benefits of Human-Horse Relationships, Pantoprazole (Protonix) vs. Omeprazole (Prilosec), Lexapro (Escitalopram) vs. Prozac (Fluoxetine), Pregabalin (Lyrica) vs. Gabapentin (Neurontin). They designed a study that tested the effect of an atypical antipsychotic and compared it with that of a typical antipsychotic to determine differences. There is also evidence that dietary intake can influence brain functioning and ultimately brain health – so make sure you’re eating an optimal diet for mental health. For the study, researchers evaluated the influence of 4 factors on brain volume including: duration of illness, antipsychotic treatment, severity of illness, and substance abuse. However, they couldn’t ignore the fact that animal studies involving administration of antipsychotics demonstrated decreases in brain tissue volume. Traumatic brain injury can be the primary cau … We propose that psychosis results from damage to the frontal and temporal areas and dysregulation of the dopaminergic system. A sad young life ruined without need tragic and unbelievable in this day and age! Oddly enough, they didn’t suggest that brain volume decreased from antipsychotic usage. This site uses Akismet to reduce spam. Researchers discover second type of schizophrenia. I’m a total crazy person, but I like being this way. Some types of brain damage from drugs are reversible, not all are. I believe psychosis is just a brain process of malfunction. Cannabidiol (CBD) Side Effects & Adverse Reactions, L-Tyrosine Side Effects & Adverse Reactions (List), Armour Thyroid Side Effects & Adverse Reactions (List), Remeron (Mirtazapine) Withdrawal Symptoms + How Long They Last, Source: http://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.2013.13030413, Source: http://www.ncbi.nlm.nih.gov/pubmed/15756305, Source: http://www.ncbi.nlm.nih.gov/pubmed/15809403, Source: http://www.ncbi.nlm.nih.gov/pubmed/19338710, Source: http://www.ncbi.nlm.nih.gov/pubmed/20085668, Source: http://www.ncbi.nlm.nih.gov/pubmed/21300943, Source: http://www.ncbi.nlm.nih.gov/pubmed/23769814, Source: http://www.ncbi.nlm.nih.gov/pubmed/23558429, Source: http://www.ncbi.nlm.nih.gov/pubmed/23172002. When I found out who they were really connected with (knowing how the Scientologists “treat” mental illness, as noted in the story above), I immediately tried to unsubscribe from their mailing list. In fact, then they started to harass me, disguised email address etc. Over time, it is known that people become tolerant to their antipsychotics and their brain changes as a result of treatment. They had undergoing neuroimaging with high-resolution MRI scans upon onset of their illness. Not suicidal or a risk to self or others but feeling overwhelmed and sad and diminished hope of gaining any resolutions, and getting too tired to help raise awareness to safeguard other humans from being harmed indefinitely like myself and lack of services or skilled professionals to help. Those that need to take antipsychotics may be alarmed by evidence suggesting that they cause brain damage over time. In other words, you should have experienced schizophrenia and/or a psychotic break. I find that VERY disturbing, and I hope more people actually research CCHR before getting involved with them. We're Here to Help. This research suggested that sizing of certain regions may actually increase with treatment. People even started to refer to these drugs as having “neuroprotective” properties, and schizophrenia was increasingly described in neo-Kraeplinian terms as a neurodegenerative condition (2) . The study was considered longitudinal, randomized, double-blind, and controlled. Fortunately, preliminary evidence suggests that volumetric decreases are more severe among rodents and non-human primates than in human populations. I think mostly superficial people want to control people. Thanks to my brain damage, I feel more purposeful and I really value the Spiritual Side of life (Which I had zero interest before I was prescribed these drugs). Psychiatry is a joke. Celexa (Citalopram) vs. Lexapro (Escitalopram): Which Is Better? I wrote to them directly and stated that I no longer wished to be on their mailing list and to take me off of it or I would take further action. Researchers noted that brain volume changes associated with schizophrenia were speculated to be a result of the disease. Long-term prognoses for those who adhere to treatment are considerably better than those who stop taking their medications. They are both kind of important for deciding how much Ap’s to take. If symptomatic relapse affects brain volume, but the number of relapses don’t affect brain volume, couldn’t this be chalked completely up to the treatment. Initially, there were no significant decreases in grey matter, white matter, or cerebrospinal fluid. In the coming years, it is hoped that a newer generation of more targeted medications help reduce symptoms of schizophrenia with fewer side effects and no brain volume loss. Additionally, a neurologist will be able to compare your baseline brain scans with those that you get during treatment to determine specific areas that may be experiencing decline. 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