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During the control period the patients were on aluminum hydroxide and calcitriol therapy and had plasma phosphorus levels less than 6 mg/dL (4.95 +/- 0.8 mg/dL). Nephrol Dial Transplant 25:3707–3717 CrossRefPubMedPubMedCentral De Francisco AL, Leidig M, Covic AC et al (2010) Evaluation of calcium acetate/magnesium carbonate as a phosphate binder compared with sevelamer hydrochloride in haemodialysis patients: a controlled randomized study (CALMAG study) assessing efficacy and tolerability. Consequently, calcium x phosphate product tended to be better controlled in the lanthanum group. Estimated RPBC for aluminum-containing binders were 1.5 for aluminum hydroxide and 1.9 for aluminum carbonate. calcium acetate, calcium carbonate (Tums, Calsan, Apocal, Ocal), calcium liquid, aluminum . Initial Dosing for patients not on a phosphate binder: 800 mg to 1600 mg orally 3 times a day with meals Based on serum phosphorus level: -Phosphorus greater than 5.5 to less than 7.5 mg/dL: 800 mg 3 times a day with meals -Phosphorus greater than or equal to 7.5 mg/dL: 1600 mg 3 times a day with meals -Titrate in increments of 800 mg 3 times a day at 2-week intervals with the goal of controlling serum phosphorus within target range. Dietary phosphorus (milligrams) = 128 + 14 (protein intake [grams]) was the best-fitting equation and explained 84% of the variance in dietary phosphorus intake. Kidney Int Suppl, 2006, 105, S10-5 Pubmed Scaria P.T., Gangadhar R., Pisharody R. Effect of lanthanum carbonate and calcium acetate in the treatment of hyperphosphatemia in patients of chronic kidney disease. The long-term implementation of this modality may result in a more optimal serum P control, without an increase in the number of or lengthening of the dialysis sessions. Despite the decrease in net intestinal absorption of calcium, the average 47Ca absorption remained unchanged, irrespective of the type and dose of antacid used. Aluminum hydroxide, calcium carbonate and calcium acetate in chronic intermittent hemodialysis patients. In this European multicentre study, 800 patients were randomised to receive either lanthanum or calcium carbonate and the dose titrated over 5 weeks to achieve control of serum phosphate. Short-Term Effects of Very-Low-Phosphate and Low-Phosphate Diets on Fibroblast Growth Factor 23 in Hemodialysis Patients: A Randomized Crossover Trial, Management of Secondary Hyperparathyroidism in Chronic Kidney Disease: A Focus on the Elderly, Management of Bone Disorders in Kidney Disease: Diagnosis and Treatment, Risk factors for persistent hyperparathyroidism in children with stable renal function after kidney transplantation, Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. All patients were instructed to ingest phosphate binders with meals. Despite dietary restrictions, patients receiving dialysis invariably experience hyperphosphatemia and require treatment with phosphate binders. Calcium carbonate is widely used as an oral phosphorus binder to control hyperphosphatemia in children on maintenance hemodialysis. The relative phosphate-binding coefficient (RPBC) based on weight of each binder can be estimated relative to calcium carbonate, the latter being set to 1.0. All patients received calcitriol regularly. Atorvastatin was added to achieve serum LDL-C levels less than 70 mg/dL in both groups. With intensive lowering of LDL-C levels for 1 year, hemodialysis patients treated with either calcium acetate or sevelamer experienced similar progression of CAC. Calcium acetate has a higher specific phosphorus-binding efficacy than calcium carbonate 371 and causes fewer hypercalcemic episodes than calcium carbonate at a given phosphate-binder dose. Whether this is a phenomenon related to the elderly or the process of dementia warrants further study. Study outcomes included the targeted concentrations of serum phosphorus, calcium, and intact parathyroid hormone (PTH), and calcification of the coronary arteries and thoracic aorta using a calcification score derived from electron beam tomography. In period 2, they took no phosphate binders for a month, and in period 3, they took calcium carbonate (Os-Cal) for two months (mean dose, … In three patients who received large therapeutic doses of antacids, 240 to 450 ml/day, the changes of calcium and phosphorus metabolism were intensified. Cardiovascular disease is frequent and severe in patients with end-stage renal disease. 2019 Oct 7;14(10):1475-1483. doi: 10.2215/CJN.04250419. The phosphate-binding equivalent dose was then defined as the dose of each binder in g × its RPBC, which would be the binding ability of an equivalent weight of calcium carbonate. Magnesium carbonate (86 mg of elemental magnesium) and calcium carbonate (100 mg of elemental calcium) were in the combination tablet.