Unfortunately, although gastric and pancreatic heterotopias are well documented, there is very little Literature available to comment on the significance of duodenal heterotopia and its presentations. Furthermore, Helicobacter pylori infections, uremia, and pancreatitis are also potentially associated with increased incidence of Brunner’s gland hamartoma . Polypoid Carcinoma. Presentation Brunner's gland hyperplasia has been attributed to multiple small polypoid or nodular lesions composed of excessive Brunner's glands separated by fibrous septa . It is estimated that they represent approximately 5–10% of benign duodenal tumors. We report an unusual case of Brunner’s gland hyperplasia leading to severe gastric outlet obstruction requiring surgical intervention. The duodenum is the first part of the small bowel and receives food from the stomach.It is accessible by EGD (esophagogastroduodenoscopy) and frequently biopsied. By and large, the stomach has been the site, albeit infrequent, for heterotopic duodenal tissue, and other sites such as the ileum rare [3-8]. In our patient, the diagnosis of duodenal heterotopia was made by visualizing Brunner’s glands in the mucosa and submucosa of the ileum (Figure 1). adj. Its size of over 8 cm makes it one of the largest described in the literature (Fig. On rare occasions, heterotopic tissue of salivary gland type as well as heterotopias of apocrine glands, thyroid, and prostatic tissue have been described. Nonneoplastic duodenal epithelial polyps include Brunner gland hyperplastic nodule/polyps (also known as Brunner gland hyperplasia), Brunner gland hamartomas, Brunner gland cysts, ectopic gastric mucosa, pancreatic heterotopia, hyperplastic polyps, inflammatory polyps, and hamartomatous polyps. Brunner Gland Nodules. -, Dig Dis Sci. The most frequent are gastric heterotopia, pancreatic heterotopia, and heterotopia of Brunner's gland. The postoperative period was uneventful and the child was discharged with advice to follow up in OPD. In our patient, it is quite likely that duodenal heterotopia in the ileum was an incidental finding that was diagnosed only because she presented with ileal perforation. Multiple lesions less than 5 mm are hyperplasia. Keywords: 18-1 ). Presentation Gastric glands - body-type or antral-type. Scott HW, Payne TPB (1947) Diffuse Congenital Cystic Hyperplasia of the Stomach, Clinically Simulating Carcinoma. Microscopic. ©2017 Kumar T, et al. Gastric metaplasia is an uncom-mon finding in children, but increases in frequency in adults and can be found in most patients (90%) with current ... tion of stem cells in the duodenal crypt or substitution by cells migrating from Brunner’s gland ducts. Kantor M, Eiseler S, Schiller A, Hughes S, Liu X, Lai J. Clin Res Hepatol Gastroenterol. Case Report. Gastric heterotopias may give rise to pyloric gland adenomas within the bowel or rarely adenocarcinomas of the esophagus. Lee WC, et al. Synonyms for Brunner glands in Free Thesaurus. In other reported cases of Brunner’s gland pathology (hyperplasia, hamartoma or adenoma), the disease is mostly confined to the duodenum, and occasionally to the stomach [3-8]. Berant M, Aviad I, Jacobs J (1965) Heterotopic duodenal mucosa in the stomach. This is due to the complex embryogenesis and the relative ease to detect heterotopic tissue during endoscopy. This is a layer of tissue full of blood vessels and nerves which supports the mucosa, or inner lining, of the gut. Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia. õ Ǵ ȹ ̼Ҽ (gastric metaplasia) ƴ ǥ Ǹ Ҽ ּ μ κ Ǽ Ǿ 64% ߻ ϴ ǰ ִ . (ABSTRACT TRUNCATED AT 250 WORDS) Duodenal heterotopia is an extremely uncommon form of heterotopia. 2008 Jun;23(3):540-543. https://doi.org/10.3346/jkms.2008.23.3.540 Microscopic. Secondly, nodules of pyloric type glands may be seen in the mucosa and termed heterotopic, although we suspect that most of these represent Brunner's glands, which are difficult to differentiate from pyloric-type glands. The… 1972 Jan-Feb;15(1):57-62 Benign. Cystic Brunner’s gland hamartoma has been described under the various names including cystic hamartoma of Brunner’s glands, cystic Brunner’s gland heterotopia, Brunner’s gland cysts, Brunner’s gland cystadenoma, Brunner’s cyst, mucocele of Brunner’s glands, and cyst of Brunner’s glands[1-4]. Pathologic Features Normal Brunner’s Glands Brunner’s glands are mucosal and submu-cosal alkaline secreting glands that are most commonly located in the duodenum, al-though they may be found infrequently in the pylorus and jejunum. In our patient, the diagnosis of duodenal heterotopia was made by visualizing Brunner’s glands in the mucosa and submucosa of the ileum (Figure 1). The Medium-sized pancreatic heterotopias, Brunner's gland heterotopias, and inflammatory fibroid polyps (mean sizes 7-10 mm) were usually located in the antrum (100%, 81%, 80%, respectively), while the other polyps had an average size of between 10 and 16 mm and were distributed equally throughout the stomach. Abbreviated BGH. Clin Case Rep Rev 3: doi: 10.15761/CCRR.1000321, Department of Surgery, Government Medical College and Hospital Sector 32, Chandigarh 160 030 India. ... Brunner gland hyperplasia, and cystic lesions in the groove or duodenal wall. Despite an exhaustive search of available Literature, we could come across only a few reports of duodenal heterotopia [3-7]. -, Exp Mol Pathol. gland 1 (glănd) n. 1. a. There were positive correlation between helicobacter pylori infection and duodenal active inflammation, Brunner gland hyperplasia, gastric metaplasia and duodenal ulcer. 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